pS357-CCR6 (phospho-Chemokine Receptor 6 Antibody)

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Agonist-induced Serine357 phosphorylation of the Chemokine Receptor 6

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Order number: 7TM0063A
Content: 100 µl
Host: Rabbit

Serine357 (S357) is a major phosphorylation site of the CCR6 receptor. The pS357-CCR6 antibody... more

Serine357 (S357) is a major phosphorylation site of the CCR6 receptor. The pS357-CCR6 antibody detects phosphorylation in response to high- and low-efficacy agonists and after PKC activation. S357 phosphorylation is a key regulator of CCR6 desensitization, β-arrestin recruitment and internalization.

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Alternative Names CCR6, CKR-L3, Chemokine Receptor 6, Chemokine (C-C motif)... more

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Alternative Names	CCR6, CKR-L3, Chemokine Receptor 6, Chemokine (C-C motif) Receptor 6, DRY-6
IUPHAR Target ID	63
UniProt ID	P51684
Western Blot (WB)	1:1000
Immunocytochemistry (ICC)	-
Species Reactivity	Human
Host / Isotype	Rabbit / IgG
Class	Polyclonal
Immunogen	A synthetic phosphopeptide derived from human CCR6 around the phosphorylation site of Ser357.
Form	Liquid
Purification	Antigen affinity chromatography
Storage buffer	Dulbecco's PBS, pH 7.4, with 150 mM NaCl, 0.02% sodium azide
Storage conditions	short-term 4°C, long-term -20°C

Figure 1. Agonist-induced Serine357 phosphorylation of the Chemokine Receptor 6. Upper panel,... more

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Figure 1. Agonist-induced Serine357 phosphorylation of the Chemokine Receptor 6. Upper panel, HEK293 cells stably expressing the Chemokine Receptor 6 (CCR6) were either not exposed or exposed to 100 nM specific Chemokine receptor 6 agonist CCL20 for 30 minutes. Cells were lysed and immunoblotted with the anti-pS357-CCR6 antibody (7TM0063A) at a dilution of 1:1000. Lower panel, blot was stripped and reprobed with an phosphorylation-independent anti-CCR6 antibody to confirm equal loading of the gel.

Be the first to decipher the CCR6 phosphorylation barcode and let us know. more

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Be the first to decipher the CCR6 phosphorylation barcode and let us know.

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