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pT360/pS361-CCR6 (phospho-Chemokine Receptor 6 Antibody)

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pT360/pS361-CCR6 (phospho-Chemokine Receptor 6 Antibody)
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  • 7TM0063B
  • 100 µl
  • Rabbit
Threonine360/Serine361 (T360/S361) is a major phosphorylation site of the CCR6 receptor.... more

Threonine360/Serine361 (T360/S361) is a major phosphorylation site of the CCR6 receptor. The pT360/pS361-CCR6 antibody detects phosphorylation in response to high- and low-efficacy agonists and after PKC activation. T360/S361 phosphorylation is a key regulator of CCR6 desensitization, β-arrestin recruitment and internalization.

  Alternative Names CCR6, CKR-L3, Chemokine Receptor 6, Chemokine (C-C motif)... more

 

Alternative Names CCR6, CKR-L3, Chemokine Receptor 6, Chemokine (C-C motif) Receptor 6, DRY-6
IUPHAR Target ID  63
UniProt ID  P51684
Western Blot (WB)  1:1000
Immunocytochemistry (ICC)  -
Species Reactivity   Human
Host / Isotype Rabbit / IgG
Class Polyclonal
Immunogen A synthetic phosphopeptide derived from human CCR6 around the phosphorylation site of Thr360/Ser361.
Form  Liquid
Purification Antigen affinity chromatography
Storage buffer Dulbecco's PBS, pH 7.4, with 150 mM NaCl, 0.02% sodium azide
Storage conditions short-term 4°C, long-term -20°C
Figure 1. Agonist-induced Threonine360/Serine361 phosphorylation of the Chemokine Receptor 6.... more

Figure 1. Agonist-induced Threonine360/Serine361 phosphorylation of the Chemokine Receptor 6. Upper panel, HEK293 cells stably expressing the Chemokine Receptor 6 (CCR6) were either not exposed or exposed to 100 nM specific Chemokine receptor 6 agonist CCL20 for 30 minutes. Cells were lysed and immunoblotted with the anti-pT360/pS361-CCR6 antibody (7TM0063B) at a dilution of 1:1000. Lower panel, blot was stripped and reprobed with an phosphorylation-independent anti-CCR6 antibody to confirm equal loading of the gel.




Be the first to decipher the CCR6 phosphorylation barcode and let us know. more

Be the first to decipher the CCR6 phosphorylation barcode and let us know.

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