Premium Phosphosite-Specific 7TM Antibodies
Novel Tools for Your GPCR Research
Select Your Country of Delivery below

pT271-M2 (phospho-M2 Muscarinic Acetylcholine Receptor Antibody)

NEW
Agonist-induced Threonine271 phosphorylation of the M2 Muscarinic Acetycholine Receptor
$ 375.00 *

Prices plus VAT plus shipping costs

Ready to ship today,
Delivery time appr. 5-8 days

  • 7TM0014A
  • 100 µl
  • Rabbit
Threonine271 is a major phosphorylation site of the M2 Muscarinic Acetylcholine Receptor. The... more

Threonine271 is a major phosphorylation site of the M2 Muscarinic Acetylcholine Receptor. The pT271-M2 antibody detects phosphorylation in response to high-efficacy agonists but not after PKC activation. T271 phosphorylation is a key regulator of M2 desensitization, β-arrestin recruitment and internalization.

  Alternative Names AChR M2, Chrm 2, Cholinergic Receptor muscarinic 2... more

 

Alternative Names AChR M2, Chrm 2, Cholinergic Receptor muscarinic 2
IUPHAR Target ID  14
UniProt ID  P08172
Western Blot (WB)  1:1000
Immunocytochemistry (ICC)  -
Species Reactivity   Human
Host / Isotype Rabbit / IgG
Class Polyclonal
Immunogen A synthetic phosphopeptide derived from human M2 around the phosphorylation site of Thr271.
Form  Liquid
Purification Antigen affinity chromatography
Storage buffer Dulbecco's PBS, pH 7.4, with 150 mM NaCl, 0.02% sodium azide
Storage conditions short-term 4°C, long-term -20°C
Figure 1. Agonist-induced Threonine271 phosphorylation of the M2 Muscarinic Acetycholine... more

Figure 1. Agonist-induced Threonine271 phosphorylation of the M2 Muscarinic Acetycholine Receptor. Upper panel, HEK293 cells stably expressing the M2 Muscarinic Acetycholine Receptor (M2) were either not exposed or exposed to 100 nM Carbachol for 30 minutes. Cells were lysed and immunoblotted with the anti-pT271-M2 antibody (7TM0014A) at a dilution of 1:1000. Lower panel, blot was stripped and reprobed with an phosphorylation-independent anti-M2 antibody to confirm equal loading of the gel.

Be the first to decipher the M2 phosphorylation barcode and let us know. more

Be the first to decipher the M2 phosphorylation barcode and let us know.

Read, write and discuss reviews... more
Customer evaluation for "pT271-M2 (phospho-M2 Muscarinic Acetylcholine Receptor Antibody)"
Write an evaluation
Evaluations will be activated after verification.

The fields marked with * are required.

Recently viewed