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pT307/pS309-M2 (phospho-M2 Muscarinic Acetylcholine Receptor Antibody)

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Agonist-induced Threonine307/Serine309 phosphorylation of the M2 Muscarinic Acetylcholine Receptor
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  • 7TM0014D
  • 100 µl
  • Rabbit
Threonine307/Serine309 is a major phosphorylation site of the M2 Muscarinic Acetylcholine... more

Threonine307/Serine309 is a major phosphorylation site of the M2 Muscarinic Acetylcholine Receptor. The pT307/pS309-M2 antibody detects phosphorylation in response to high-efficacy agonists but not after PKC activation. T307/S309 phosphorylation is a key regulator of M2 desensitization, β-arrestin recruitment and internalization.

  Alternative Names AChR M2, Chrm 2, Cholinergic Receptor muscarinic 2... more

 

Alternative Names AChR M2, Chrm 2, Cholinergic Receptor muscarinic 2
IUPHAR Target ID  14
UniProt ID  P08172
Western Blot (WB)  1:1000
Immunocytochemistry (ICC)  -
Species Reactivity   Human
Host / Isotype Rabbit / IgG
Class Polyclonal
Immunogen A synthetic phosphopeptide derived from human M2 around the phosphorylation site of Thr307/Ser309.
Form  Liquid
Purification Antigen affinity chromatography
Storage buffer Dulbecco's PBS, pH 7.4, with 150 mM NaCl, 0.02% sodium azide
Storage conditions short-term 4°C, long-term -20°C
Figure 1. Agonist-induced Threonine307/Serine309 phosphorylation of the M2 Muscarinic... more

Figure 1. Agonist-induced Threonine307/Serine309 phosphorylation of the M2 Muscarinic Acetylcholine Receptor. Upper panel, HEK293 cells stably expressing the M2 Muscarinic Acetylcholine Receptor (M2) were either not exposed or exposed to 100 nM Carbachol for 30 minutes. Cells were lysed and immunoblotted with the anti-pT307/pS309-M2 antibody (7TM0014D) at a dilution of 1:1000. Lower panel, blot was stripped and reprobed with an phosphorylation-independent anti-M2 antibody to confirm equal loading of the gel.

Be the first to decipher the M2 phosphorylation barcode and let us know. more

Be the first to decipher the M2 phosphorylation barcode and let us know.

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