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pS359/pT361-M3 (phospho-M3 Muscarinic Acetylcholine Receptor Antibody)

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Agonist-induced Serine359/Threonine361 phosphorylation of the M3 Muscarinic Acetylcholine Receptor
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  • 7TM0015B
  • 100 µl
  • Rabbit
Serine359/Threonine361 is a major phosphorylation site of the M3 Muscarinic Acetylcholine... more

Serine359/Threonine361 is a major phosphorylation site of the M3 Muscarinic Acetylcholine Receptor. The pS359/pT361-M3 antibody detects phosphorylation in response to high-efficacy agonists but not after PKC activation. S359/T361 phosphorylation is a key regulator of M3 desensitization, β-arrestin recruitment and internalization.

  Alternative Names HM4, Chrm 3, Cholinergic Receptor muscarinic 3... more

 

Alternative Names HM4, Chrm 3, Cholinergic Receptor muscarinic 3
IUPHAR Target ID  15
UniProt ID  P20309
Western Blot (WB)  1:1000
Immunocytochemistry (ICC)  -
Species Reactivity   Human
Host / Isotype Rabbit / IgG
Class Polyclonal
Immunogen A synthetic phosphopeptide derived from human M3 around the phosphorylation site of Ser359/Thr361.
Form  Liquid
Purification Antigen affinity chromatography
Storage buffer Dulbecco's PBS, pH 7.4, with 150 mM NaCl, 0.02% sodium azide
Storage conditions short-term 4°C, long-term -20°C
Figure 1. Agonist-induced Serine359/Threonine361 phosphorylation of the M3 Muscarinic... more

Figure 1. Agonist-induced Serine359/Threonine361 phosphorylation of the M3 Muscarinic Acetylcholine Receptor. Upper panel, HEK293 cells stably expressing the M3 Muscarinic Acetylcholine Receptor (M3) were either not exposed or exposed to 100 µM Acetylcholine for 30 minutes. Cells were lysed and immunoblotted with the anti-pS359/pT361-M3 antibody (7TM0015B) at a dilution of 1:1000. Lower panel, blot was stripped and reprobed with an phosphorylation-independent anti-5-HT4 antibody to confirm equal loading of the gel.

Be the first to decipher the M3 phosphorylation barcode and let us know. more

Be the first to decipher the M3 phosphorylation barcode and let us know.

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