![pS338/pS339-DP2 (phospho-DP2 Prostanoid Receptor Antibody)](https://7tmantibodies.com/media/image/e1/b5/02/pS338-pS339-DP2-F1yvvsBUbt9TNAn_600x600.png)
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- Order number: 7TM0339A
- Content: 100 µl
- Host: Rabbit
Serine338/Serine339 (S338/S339) is major phosphorylation site of the DP2 Prostanoid Receptor (DP2). The pS338/pS339-DP2 antibody detects phosphorylation in response to agonists. S338/S339 phosphorylation is likely to be involved in efficient ligand sequestration by DP2.
Alternative Names | Prostaglandin D2 Receptor 2, PGD2 Receptor |
IUPHAR Target ID | 339 |
UniProt ID | Q9Y5Y4 |
Western Blot (WB) | 1:1000 |
Species Reactivity | Human |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Immunogen | A synthetic phosphopeptide derived from human DP2 around the phosphorylation site of Ser338/Ser339. |
Form | Liquid |
Purification | Antigen affinity chromatography |
Storage buffer | Dulbecco's PBS, pH 7.4, with 150 mM NaCl, 0.02% sodium azide |
Storage conditions | short-term 4°C, long-term -20°C |
Figure 1. Agonist-induced Serine338/Serine339 phosphorylation of the Prostanoid Receptor 2. Upper panel, HEK293 cells stably expressing the Prostanoid receptor 2 (DP2) were either not exposed or exposed to 10 µM Treprostinil for 30 minutes. Cells were lysed and immunoblotted with the anti-pS338/pS339-DP2 antibody (7TM0339A) at a dilution of 1:1000. Lower panel, blot was stripped and reprobed with an phosphorylation-independent anti-DP2 antibody to confirm equal loading of the gel.
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