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pT344/pS347-NK1 (phospho-Tachykinin Receptor 1 Antibody)

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pT344/pS347-NK1 (phospho-Tachykinin Receptor 1 Antibody)
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  • 7TM0360A
  • 100 µl
  • Rabbit
Threonine344/Serine347 (T344/S347) is a major phosphorylation site of the NK1 receptor.... more

Threonine344/Serine347 (T344/S347) is a major phosphorylation site of the NK1 receptor. The pT344/pS347-NK1 antibody detects phosphorylation in response to high-efficacy agonists. T344/S347 phosphorylation is a key regulator of NK1 desensitization, β-arrestin recruitment and internalization.

  Alternative Names NK1, SPR, TACR1, Neurokinin Receptor 1, Substance P... more

 

Alternative Names NK1, SPR, TACR1, Neurokinin Receptor 1, Substance P Receptor
IUPHAR Target ID  360
UniProt ID  P25103
Western Blot (WB)  1:1000
Immunocytochemistry (ICC)  -
Species Reactivity   Human
Host / Isotype Rabbit / IgG
Class Polyclonal
Immunogen A synthetic phosphopeptide derived from human NK1 around the phosphorylation site Thr344/Ser347.
Form  Liquid
Purification Antigen affinity chromatography
Storage buffer Dulbecco's PBS, pH 7.4, with 150 mM NaCl, 0.02% sodium azide
Storage conditions short-term 4°C, long-term -20°C
Figure 1. Agonist-induced Threonine344/Serine347 phosphorylation of NK1 Receptor. Upper... more

Figure 1. Agonist-induced Threonine344/Serine347 phosphorylation of NK1 Receptor. Upper panel, HEK293 cells stably expressing the NK1-Receptor (NK1) were either not exposed or exposed to 1 µM of specific NK1-Receptor agonist Substance P for 30 minutes. Cells were lysed and immunoblotted with the anti-pT344/pS347-NK1 antibody (7TM0360A) at a dilution of 1:1000. Lower panel, blot was stripped and reprobed with the phosphorylation-independent anti-NK1 antibody (7TM0360N) at a dilution of 1:1000 to confirm equal loading of the gel.

Blum NK, Schaffner A, Drube J, Nagel F, Reinscheid RK, Hoffmann C, Schulz S. Rapid elucidation... more

Blum NK, Schaffner A, Drube J, Nagel F, Reinscheid RK, Hoffmann C, Schulz S. Rapid elucidation of agonist-driven regulation of the neurokinin 1 receptor using a GPCR phosphorylation immunoassay. Eur J Pharmacol. 2024 Jun 15;973:176587. doi: 10.1016/j.ejphar.2024.176587. Epub 2024 Apr 19. PMID: 38642667.

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