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Prostanoid Receptor Antibodies

Prostanoid receptors are activated by the endogenous ligands prostaglandins PGD2, PGE1, PGE2 , PGF2α, PGH2, prostacyclin (PGI2) and thromboxane A2. Cyclo-oxygenase (COX) converts arachidonic acid to prostaglandin H2 (PGH2), from which further prostanoids, PGD2, PGE2, PGF2α, PGI2 (prostacyclin) and thromboxane A2 (TXA2) are enzymatically derived. Based on the agonist potencies of the latter prostanoids (and the limited use of receptor antagonists), five prostanoid receptors were recognized and correspondingly named DP, EP, FP, IP and TP receptors. Additionally, EP receptors have been subdivided into four groups, termed EP1, EP2, EP3 and EP4. cDNA cloning identified a family of eight G-protein coupled receptors (GPCRs) that correspond to these pharmacologically-defined receptors. cDNA cloning also revealed the presence of an additional GPCR called CRTH2 that mediates some PGD2 actions. Therefore, the DP receptor now has two subtypes, DP1 and DP2 (CRTH2).

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Agonist-induced Serine374/Serine377 phosphorylation of the EP4 Prostanoid Receptor
pS374/pS377-EP4 (phospho-EP4 Prostanoid...
Serine374/Serine377 (S374/S377) is major phosphorylation site of the EP4 Prostanoid Receptor (EP4). The pS374/pS377-EP4 antibody detects phosphorylation in response to agonists. S374/S377 phosphorylation is likely to be involved in...
$ 350.00
NEW
Agonist-induce Serine364/Serine366 phosphorylation of the EP4 Prostanoid Receptor
pS364/pS366-EP4 (phospho-EP4 Prostanoid...
Serine364/Serine366 (S364/S366) is major phosphorylation site of the EP4 Prostanoid Receptor (EP4). The pS364/pS366-EP4 antibody detects phosphorylation in response to agonists. S364/S366 phosphorylation is likely to be involved in...
$ 350.00
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pT369/pS370-EP4 (phospho-EP4 Prostanoid Receptor Antibody)
pT369/pS370-EP4 (phospho-EP4 Prostanoid...
Threonine369/Serine370 (T369/S370) is major phosphorylation site of the EP4 Prostanoid Receptor (EP4). The pT369/pS370-EP4 antibody detects phosphorylation in response to agonists. T369/S370 phosphorylation is likely to be involved in...
$ 350.00
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pS338/pS339-DP2 (phospho-DP2 Prostanoid Receptor Antibody)
pS338/pS339-DP2 (phospho-DP2 Prostanoid...
Serine338/Serine339 (S338/S339) is major phosphorylation site of the DP2 Prostanoid Receptor (DP2). The pS338/pS339-DP2 antibody detects phosphorylation in response to agonists. S338/S339 phosphorylation is likely to be involved in...
$ 350.00
NEW
Agonist-induced Threonine344/Serine345 phosphorylation of the Prostanoid Receptor 2
pT344/pS345-DP2 (phospho-DP2 Prostanoid...
Threonine344/Serine345 (T344/S345) is major phosphorylation site of the DP2 Prostanoid Receptor (DP2). The pT344/pS345-DP2 antibody detects phosphorylation in response to agonists. T344/S345 phosphorylation is likely to be involved in...
$ 350.00
NEW
Agonist-induced Threonine342/Threonine344 phosphorylation of the EP2 Prostanoid Receptor
pT342/pT344-EP2 (phospho-EP2 Prostanoid...
Threonine342/Threonine344 (T342/T344) is major phosphorylation site of the EP2 Prostanoid Receptor (EP2). The pT342/pT344-EP2 antibody detects phosphorylation in response to agonists. T342/T344 phosphorylation is likely to be involved in...
$ 350.00
NEW
Agonist-induced Threonine344/Serine345 phosphorylation of the EP2 Prostanoid Receptor
pT344/pS345-EP2 (phospho-EP2 Prostanoid...
Threonine344/Serine345 (T344/S345) is major phosphorylation site of the EP2 Prostanoid Receptor (EP2). The pT344/pS345-EP2 antibody detects phosphorylation in response to agonists. T344/S345 phosphorylation is likely to be involved in...
$ 350.00
NEW
Agonist-induced Serine347/Threonine348phosphorylation of the EP2 Prostanoid Receptor
pS347/pT348-EP2 (phospho-EP2 Prostanoid...
Serine347/Threonine348 (S347/T348) is major phosphorylation site of the EP2 Prostanoid Receptor (EP2). The pS347/pT348-EP2 antibody detects phosphorylation in response to agonists. S347/T348 phosphorylation is likely to be involved in...
$ 350.00
NEW
Agonist-induced Serine369/Serine370 phosphorylation of the EP3 Prostanoid Receptor
pS369/pS370-EP3 (phospho-EP3 Prostanoid...
Serine369/Serine370 (S369/S370) is major phosphorylation site of the EP3 Prostanoid Receptor (EP3). The pS369/pS370-EP3 antibody detects phosphorylation in response to agonists. S369/S370 phosphorylation is likely to be involved in...
$ 350.00
NEW
Agonist-induced Threonine372/Serine373 phosphorylation of the EP3 Prostanoid Receptor
pT372/pS373-EP3 (phospho-EP3 Prostanoid...
Threonine372/Serine373 (T372/S373) is major phosphorylation site of the EP3 Prostanoid Receptor (EP3). The pT372/pS373-EP3 antibody detects phosphorylation in response to agonists. T372/S373 phosphorylation is likely to be involved in...
$ 350.00
NEW
Agonist-induced Serine379/Serine380 phosphorylation of the EP3 Prostanoid Receptor
pS379/pS380-EP3 (phospho-EP3 Prostanoid...
Serine379/Serine380 (S379/S380) is major phosphorylation site of the EP3 Prostanoid Receptor (EP3). The pS379/pS380-EP3 antibody detects phosphorylation in response to agonists. S379/S380 phosphorylation is likely to be involved in...
$ 350.00
NEW
Agonist-induced Serine319/Threonine321 phosphorylation of the IP Prostacyclin Receptor
pS319/pT321-IP (phospho-IP Prostacyclin...
Serine319/Threonine321 (S319/T321) is major phosphorylation site of the IP Prostacyclin Receptor (IP). The pS319/pT321-IP antibody detects phosphorylation in response to agonists. S319/T321 phosphorylation is likely to be involved in...
$ 350.00
NEW
Agonist-induced Serine324/Serine328 phosphorylation of the IP Prostacyclin Receptor
pS324/pS328-IP (phospho-IP Prostacyclin...
Serine324/Serine328 (S324/S328) is major phosphorylation site of the IP Prostacyclin Receptor (IP). The pS324/pS328-IP antibody detects phosphorylation in response to agonists. S324/S328 phosphorylation is likely to be involved in...
$ 350.00
NEW
Agonist-induced Threonine337/Serine340 phosphorylation of the TP Thromboxane Receptor
pT337/pS340-TP (phospho-TP Thromboxane Receptor...
Threonine337/Serine340 (T337/S340) is major phosphorylation site of the TP Thromboxane Receptor (TP). The pT337/pS340-TP antibody detects phosphorylation in response to agonists. T337/S340 phosphorylation is likely to be involved in...
$ 350.00

For more information on prostanoid receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Coleman RA, Smith WL, Narumiya S. International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes. Pharmacol Rev. 1994 Jun;46(2):205-29. PMID: 7938166.

Woodward DF, Jones RL, Narumiya S. International Union of Basic and Clinical Pharmacology. LXXXIII: classification of prostanoid receptors, updating 15 years of progress. Pharmacol Rev. 2011 Sep;63(3):471-538. doi: 10.1124/pr.110.003517. PMID: 21752876.

For more information on prostanoid receptor pharmacology please refer to the  IUPHAR  database. For further reading refer to: Coleman RA, Smith WL, Narumiya S. International Union of... read more »
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Prostanoid Receptor Antibodies

For more information on prostanoid receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Coleman RA, Smith WL, Narumiya S. International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes. Pharmacol Rev. 1994 Jun;46(2):205-29. PMID: 7938166.

Woodward DF, Jones RL, Narumiya S. International Union of Basic and Clinical Pharmacology. LXXXIII: classification of prostanoid receptors, updating 15 years of progress. Pharmacol Rev. 2011 Sep;63(3):471-538. doi: 10.1124/pr.110.003517. PMID: 21752876.

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