Premium Phosphosite-Specific 7TM Antibodies
Novel Tools for Your GPCR Research
Select Your Country of Delivery below

pS435/pT438-VPAC1 (phospho-VIP Receptor 1 Antibody)

NEW
 Agonist-induced and Agonist-independent Serine435/Threonine438 phosphorylation of VAPC1 Receptor
$ 350.00 *

Prices plus VAT plus shipping costs

Ready to ship today,
Delivery time appr. 5-8 days

  • 7TM0371C
  • 100 µl
  • Rabbit
Serine435/Threonine438 (S435/T438) is a major phosphorylation site of the VPAC1... more

Serine435/Threonine438 (S435/T438) is a major phosphorylation site of the VPAC1 receptor. The pS435/pT438-VPAC1 antibody detects phosphorylation in response to high-efficacy agonists. S422/S425 phosphorylation is a key regulator of VPAC1 desensitization, β-arrestin recruitment and internalization. S435/T438 also undergoes constitutive phosphorylation.

  Alternative Names VPAC1, VIP Receptor 1, Vasoactive Intestinal Peptide... more

 

Alternative Names VPAC1, VIP Receptor 1, Vasoactive Intestinal Peptide Receptor 1
IUPHAR Target ID  371
UniProt ID  P32241
Western Blot (WB)  1:1000
Immunocytochemistry (ICC)  -
Species Reactivity   Human
Host / Isotype Rabbit / IgG
Class Polyclonal
Immunogen A synthetic phosphopeptide derived from human VPAC1 around the phosphorylation site Ser435/Thr438.
Form  Liquid
Purification Antigen affinity chromatography
Storage buffer Dulbecco's PBS, pH 7.4, with 150 mM NaCl, 0.02% sodium azide
Storage conditions short-term 4°C, long-term -20°C
Figure 1. Agonist-induced and Agonist-independent Serine435/Threonine438 phosphorylation of... more

Figure 1. Agonist-induced and Agonist-independent Serine435/Threonine438 phosphorylation of VAPC1 Receptor. Upper panel, HEK293 cells stably expressing the VPAC1-Receptor (VPAC1) were either not exposed or exposed to 1 µM of specific VPAC1-Receptor agonist PACAP-27 for 30 minutes. Cells were lysed and immunoblotted with the anti-pS435/pT438-VPAC1 antibody (7TM0371C) at a dilution of 1:1000. Lower panel, blot was stripped and reprobed with the phosphorylation-independent anti-VPAC1 antibody (7TM0371N) at a dilution of 1:1000 to confirm equal loading of the gel.

 

 

Read, write and discuss reviews... more
Customer evaluation for "pS435/pT438-VPAC1 (phospho-VIP Receptor 1 Antibody)"
Write an evaluation
Evaluations will be activated after verification.

The fields marked with * are required.

Recently viewed