pS361-SST3 (phospho-Somatostatin Receptor 3 Antibody)

Agonist-induced Serine361 phosphorylation of the Somatostatin Receptor 3

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Order number: 7TM0357C
Content: 100 µl
Host: Rabbit

Serine361 (T361) is a major phosphorylation site of the somatostatin receptor 3 (SST3). The... more

Serine361 (T361) is a major phosphorylation site of the somatostatin receptor 3 (SST3). The pS361-SST3 antibody detects phosphorylation in response to high- and low-efficacy agonists but not after PKC activation. S361 phosphorylation is a key regulator of SST3 desensitization, β-arrestin recruitment and internalization.

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Alternative Names SST3, SSTR3, Somatostatin Receptor 3 IUPHAR... more

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Alternative Names	SST3, SSTR3, Somatostatin Receptor 3
IUPHAR Target ID	357
UniProt ID	P32745
Western Blot (WB)	1:1000
Species Reactivity	Human
Host / Isotype	Rabbit / IgG
Class	Polyclonal
Immunogen	A synthetic phosphopeptide derived from human SST3 around the phosphorylation site of Ser361.
Form	Liquid
Purification	Antigen affinity chromatography
Storage buffer	Dulbecco's PBS, pH 7.4, with 150 mM NaCl, 0.02% sodium azide
Storage conditions	short-term 4°C, long-term -20°C

Figure 1. Agonist-induced Serine361 phosphorylation of the Somatostatin Receptor 3. Upper... more

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Figure 1. Agonist-induced Serine361 phosphorylation of the Somatostatin Receptor 3. Upper panel, HEK293 cells stably expressing the Somatostatin Receptor 3 (SST3) were either not exposed or exposed to 1 μM SRIF (somatotropin-release inhibiting factor) for 30 minutes. Cells were lysed and immunoblotted with the anti-pS361-SST3 antibody (7TM0357C) at a dilution of 1:1000. Lower panel, blot was stripped and reprobed with the phosphorylation-independent anti-SST3 antibody (7TM0357N) at a dilution of 1:1000 to confirm equal loading of the gel.

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