![Agonist-induced Serine361 phosphorylation of the Somatostatin Receptor 3](https://7tmantibodies.com/media/image/5b/66/f4/pS361-SST3-F1-NEW_600x600.png)
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- Order number: 7TM0357C
- Content: 100 µl
- Host: Rabbit
Serine361 (T361) is a major phosphorylation site of the somatostatin receptor 3 (SST3). The pS361-SST3 antibody detects phosphorylation in response to high- and low-efficacy agonists but not after PKC activation. S361 phosphorylation is a key regulator of SST3 desensitization, β-arrestin recruitment and internalization.
Alternative Names | SST3, SSTR3, Somatostatin Receptor 3 |
IUPHAR Target ID | 357 |
UniProt ID | P32745 |
Western Blot (WB) | 1:1000 |
Species Reactivity | Human |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Immunogen | A synthetic phosphopeptide derived from human SST3 around the phosphorylation site of Ser361. |
Form | Liquid |
Purification | Antigen affinity chromatography |
Storage buffer | Dulbecco's PBS, pH 7.4, with 150 mM NaCl, 0.02% sodium azide |
Storage conditions | short-term 4°C, long-term -20°C |
Figure 1. Agonist-induced Serine361 phosphorylation of the Somatostatin Receptor 3. Upper panel, HEK293 cells stably expressing the Somatostatin Receptor 3 (SST3) were either not exposed or exposed to 1 μM SRIF (somatotropin-release inhibiting factor) for 30 minutes. Cells were lysed and immunoblotted with the anti-pS361-SST3 antibody (7TM0357C) at a dilution of 1:1000. Lower panel, blot was stripped and reprobed with the phosphorylation-independent anti-SST3 antibody (7TM0357N) at a dilution of 1:1000 to confirm equal loading of the gel.