pT361/pS363-DOP (phospho-∂-Opioid Receptor Antibody)

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Agonist-induced Threonine361/Serine363 phosphorylation of the δ-Opioid receptor

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Order number: 7TM0317D
Content: 100 µl
Host: Rabbit

Threonine361/Serine363 (T361/S363) is the primary phosphorylation site in a hierarchical... more

Threonine361/Serine363 (T361/S363) is the primary phosphorylation site in a hierarchical phosphorylation cascade of the delta-opioid receptor (DOP). The pT361/pS363-DOP antibody detects phosphorylation in response to high- and low-efficacy agonists but not after PKC activation. T361/S363 phosphorylation is a key regulator of DOP desensitization, β-arrestin recruitment and internalization.

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Alternative Names DOP, OPRD1, δ-Opioid Receptor IUPHAR Target ID... more

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Alternative Names	DOP, OPRD1, δ-Opioid Receptor
IUPHAR Target ID	317
UniProt ID	P41143 (human) P32300 (mouse) P33533 (rat)
Western Blot (WB)	1:1000
Species Reactivity	Human, Mouse, Rat
Host / Isotype	Rabbit / IgG
Class	Polyclonal
Immunogen	A synthetic phosphopeptide derived from human DOP around the phosphorylation site of Thr361/Ser363.
Form	Liquid
Purification	Antigen affinity chromatography
Storage buffer	Dulbecco's PBS, pH 7.4, with 150 mM NaCl, 0.02% sodium azide
Storage conditions	short-term 4°C, long-term -20°C

Figure 1. Agonist-induced Threonine361/Serine363 phosphorylation of the δ-Opioid receptor.... more

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Figure 1. Agonist-induced Threonine361/Serine363 phosphorylation of the δ-Opioid receptor. Upper panel, HEK293 cells stably expressing the δ-Opioid Receptor (DOP) were either not exposed or exposed to 10 μM DPDPE ([D-Pen2,D-Pen5]-enkephalin) for 30 minutes. Cells were lysed and immunoblotted with the anti-pT361/pS363-DOP antibody (7TM0317D) at a dilution of 1:1000. Lower panel, blot was stripped and reprobed with the phosphorylation-independent anti-DOP antibody (7TM0317N) at a dilution of 1:1000 to confirm equal loading of the gel.

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